Article
Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.
The Journal of biological chemistry - 3 Sept 2010
Bruce Stephen J, Butterfield Natalie C, Metzis Vicki, Town Liam, McGlinn Edwina, Wicking Carol
Abstract excerpt
The bones of the vertebrate limb form by the process of endochondral ossification, whereby limb mesenchyme condenses to form an intermediate cartilage scaffold that is then replaced by bone. Although Indian hedgehog (IHH) is known to control hypertophic differentiation of chondrocytes during this process, the role of hedgehog signaling in the earlier stages of chondrogenesis is less clear. We have conditionally...
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