Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels.

doi:10.1016/j.resp.2010.05.016

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Article

Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels.

Respiratory physiology & neurobiology - 31 Jul 2010

Telezhkin Vsevolod, Brazier Stephen P, Cayzac Sebastien H, Wilkinson William J, Riccardi Daniela, Kemp Paul J

Abstract excerpt

Recent evidence suggests that H(2)S contributes to activation of the carotid body by hypoxia by inhibiting K(+) channels. Here, we determine both the molecular identity of the K(+) channel target within the carotid body and the biophysical characteristics of the H(2)S-evoked inhibition by analyzing native rat and human recombinant BK(Ca) channel activity in voltage-clamped, inside-out membrane patches. Rat glomus...

Topics

Air Pollutants
Animals
Carotid Body
Cell Line
Cystathionine beta-Synthase
Cystathionine gamma-Lyase
Electrophysiology
Humans
Hydrogen Sulfide
Immunohistochemistry
Large-Conductance Calcium-Activated Potassium Channels
Male
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Patch-Clamp Techniques

Potassium Channel Blockers

Potassium Cyanide

RNA, Messenger

Rats

Source

Open in PubMed

Identifiers

PMID: 20576528
DOI: 10.1016/j.resp.2010.05.016

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