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Article

Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO.

The Journal of biological chemistry - 25 Jun 2010

Yi Li, Morgan Jeffrey T, Ragsdale Stephen W

Abstract excerpt

Heme is a required prosthetic group in many electron transfer proteins and redox enzymes. The human BK channel, which is a large-conductance Ca(2+) and voltage-activated K(+) channel, is involved in the hypoxic response in the carotid body. The BK channel has been shown to bind and undergo inhibition by heme and activation by CO. Furthermore, evidence suggests that human heme oxygenase-2 (HO2) acts as an oxygen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20427280
DOI: 10.1074/jbc.M110.116483
PMCID: PMC2888424

Genes

HBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO.PMID 20427280Read ↗

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