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Article

Cysteine residues in the C-terminal tail of the human BK(Ca)alpha subunit are important for channel sensitivity to carbon monoxide.

Advances in experimental medicine and biology - 1 Jan 2009

Brazier S P, Telezhkin V, Mears R, Müller C T, Riccardi D, Kemp P J

Abstract excerpt

In the presence of oxygen (O(2)), carbon monoxide (CO) is synthesised from heme by endogenous hemeoxygenases, and is a powerful activator of BK(Ca) channels. This transduction pathway has been proposed to contribute to cellular O(2) sensing in rat carotid body. In the present study we have explored the role that four cysteine residues (C820, C911, C995 and C1028), located in the vicinity of the "calcium bowl" of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19536464
DOI: 10.1007/978-90-481-2259-2_5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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