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Article

Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine.

Experimental cell research - 10 Sept 2016

Wang Yuwen, Wang Xiyao, Liang Xiaohui, Wu Jichao, Dong Shiyun, Li Hongzhu, Jin Meili, Sun Dianjun, Zhang Weihua, Zhong Xin

Abstract excerpt

Hyperhomocysteinemia induces the proliferation of vascular smooth muscle cells (VSMCs). Hydrogen sulfide (H2S) inhibits the phenotype switch of VSMCs and calcium-sensing receptor (CaSR) regulated the production of endogenous H2S. However, whether CaSR inhibits the proliferation of VSMCs by regulating the endogenous cystathionine-gamma-lyase (CSE, a major enzyme that produces H2S) pathway in high homocysteine...

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PMID: 27502588
DOI: 10.1016/j.yexcr.2016.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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