Article
Acute hypoxia differentially regulates K(+) channels. Implications with respect to cardiac arrhythmia.
European biophysics journal : EBJ - 1 Jul 2005
Hool Livia C
Abstract excerpt
The first ion channels demonstrated to be sensitive to changes in oxygen tension were K(+) channels in glomus cells of the carotid body. Since then a number of hypoxia-sensitive ion channels have been identified. However, not all K(+) channels respond to hypoxia alike. This has raised some debate about how cells detect changes in oxygen tension. Because ion channels respond rapidly to hypoxia it has been proposed...
Topics
- Animals
- Arrhythmias, Cardiac
- Biophysics
- Dose-Response Relationship, Drug
- Electrophysiology
- Humans
- Hydrogen Peroxide
- Hypoxia
- Ions
- Long QT Syndrome
- Models, Biological
- Mutation