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Article

Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels.

Nature - 2 Oct 2003

Tang Xiang Dong, Xu Rong, Reynolds Mark F, Garcia Maria L, Heinemann Stefan H, Hoshi Toshinori

Abstract excerpt

Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic group. A class of ion channel, the large-conductance calcium-dependent Slo1 BK channels, possesses...

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Source

Identifiers

PMID: 14523450
DOI: 10.1038/nature02003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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