Article
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.
European journal of pharmacology - 10 Jan 2011
Jensen Kristian K, Geoghagen Neil S, Jin Lan, Holt Tom G, Luo Qi, Malkowitz Lorraine, Ni Weihua, Quan Shuo, Waters M Gerard, Zhang Aiwu, Zhou Heather H, Cheng Kang, Luo Ming-Juan
Abstract excerpt
Hydrogen sulfide (H(2)S) is a recently discovered gasotransmitter found in mammalian tissues and blood. Treatment with H(2)S donor molecules has shown promising results in preclinical models of inflammatory and cardiovascular diseases. Augmentation of H(2)S levels thus holds promise as a novel therapeutic approach for treatment of disease in man. Cystathionine β-synthase (CBS) has been shown to catalyze H(2)S...
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