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Article

Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics.

Pediatric pulmonology - 1 Jul 2010

Löfgren Johan, Marttila Riitta, Renko Marjo, Rämet Mika, Hallman Mikko

Abstract excerpt

The respiratory syncytial virus (RSV) antigen serves as ligand for Toll-like receptor (TLR) 4 that is a transmembrane signaling receptor in macrophages and dendritic cells. According to current evidence single nucleotide polymorphism involving amino acid 299 influences the susceptibility to severe RSV infections. The Asp299Gly allele has been shown to influence the TLR4-mediated signaling causing conformational...

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Identifiers

PMID: 20575099
DOI: 10.1002/ppul.21248

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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