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Article

Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.

The Journal of infectious diseases - 1 Jun 2004

Tal Guy, Mandelberg Avigdor, Dalal Ilan, Cesar Karine, Somekh Eli, Tal Asher, Oron Anat, Itskovich Svetlana, Ballin Ami, Houri Sion, Beigelman Avraham, Lider Ofer, Rechavi Gideon, Amariglio Ninette

Abstract excerpt

BACKGROUND: The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV. METHODS: The association of the TLR4 mutations (Asp299Gly and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15143473
DOI: 10.1086/420830

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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