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Article

TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.

PloS one - 10 Aug 2010

Douville Renée N, Lissitsyn Yuriy, Hirschfeld Aaron F, Becker Allan B, Kozyrskyj Anita L, Liem Joel, Bastien Nathalie, Li Yan, Victor Rachel E, Sekhon Mehtab, Turvey Stuart E, HayGlass Kent T

Abstract excerpt

BACKGROUND: A broad variety of natural environmental stimuli, genotypic influences and timing all contribute to expression of protective versus maladaptive immune responses and the resulting clinical outcomes in humans. The role of commonly co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms Asp299Gly and Thr399Ile in this process remains highly controversial. Moreover, what...

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Identifiers

PMID: 20711470
DOI: 10.1371/journal.pone.0012087
PMCID: PMC2919413

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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