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Article

Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms with the risk of severe RSV infection: a meta-analysis.

Influenza and other respiratory viruses - 1 May 2016

Zhou Jiahui, Zhang Xiangning, Liu Shuming, Wang Ziyou, Chen Qicong, Wu Yongfu, He Zhiwei, Huang Zunnan

Abstract excerpt

Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll-like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case-control studies reported the influence of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C-159T polymorphisms on the risk of severe RSV infection. However, a decisive conclusion has not...

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Identifiers

PMID: 26901241
DOI: 10.1111/irv.12378
PMCID: PMC4814857

Genes

TLR4

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