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Article

Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevance.

Clinical immunology (Orlando, Fla.) - 1 Jun 2007

Paulus Stéphane C, Hirschfeld Aaron F, Victor Rachel E, Brunstein John, Thomas Eva, Turvey Stuart E

Abstract excerpt

Evidence suggests that Toll-like receptor 4 (TLR4) contributes to immune recognition of respiratory syncytial virus (RSV). The TLR4 gene harbours a polymorphism-Asp299Gly-previously associated with reduced TLR4 signalling. To understand of how host genetic variation influences the outcome of RSV infection in children, we examined the association between the TLR4 299Gly allele and severe RSV disease. By genotyping...

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Source

Identifiers

PMID: 17449325
DOI: 10.1016/j.clim.2007.03.003

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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