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Article

Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.

PloS one - 1 Jan 2012

Lavoie Pascal M, Ladd Mihoko, Hirschfeld Aaron F, Huusko Johanna, Mahlman Mari, Speert David P, Hallman Mikko, Lacaze-Masmonteil Thierry, Turvey Stuart E

Abstract excerpt

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease and major risk factor for severe respiratory syncytial virus (RSV) infection among preterm infants. The Toll-like receptor 4 (TLR4) is involved in oxidative injury responses in the lungs. Two non-synonymous single nucleotide polymorphisms in the TLR4 gene have been associated with RSV infection in children. However, it is unclear to what extent...

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Source

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Identifiers

PMID: 22348075
DOI: 10.1371/journal.pone.0031351
PMCID: PMC3279371

Genes

TLR4

Variants

rs4986790
rs4986790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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