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Article

Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2007

Awomoyi Agnes A, Rallabhandi Prasad, Pollin Toni I, Lorenz Eva, Sztein Marcelo B, Boukhvalova Marina S, Hemming Val G, Blanco Jorge C G, Vogel Stefanie N

Abstract excerpt

Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Although anti-RSV Ab prophylaxis has greatly reduced infant mortality in the United States, there is currently no vaccine or effective antiviral therapy. RSV fusion (F) protein activates cells through TLR4. Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile substitutions in the TLR4 ectodomain were...

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Source

Identifiers

PMID: 17709532
DOI: 10.4049/jimmunol.179.5.3171

Genes

TLR4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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