Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How does the Schwann cell lineage form tumors in NF1?

Glia - 1 Nov 2008

Carroll Steven L, Ratner Nancy

Abstract excerpt

Neurofibromas are benign tumors of peripheral nerve that occur sporadically or in patients with the autosomal dominant tumor predisposition syndrome neurofibromatosis type 1 (NF1). Multiple neurofibroma subtypes exist which differ in their site of occurrence, their association with NF1, and their tendency to undergo transformation to become malignant peripheral nerve sheath tumors (MPNSTs), the most common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Neurofibromatosis 1

Share to Peripheral Nervous System

Share to Schwann Cells

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 18803326
DOI: 10.1002/glia.20776
PMCID: PMC2652636

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How does the Schwann cell lineage form tumors in NF1?PMID 18803326Read ↗

Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.Semantic proximity Read ↗

Neurofibroma Development in Neurofibromatosis Type 1: Insights from Cellular Origin and Schwann Cell Lineage DevelopmentSemantic proximity Read ↗

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo PathwaySemantic proximity Read ↗

The NF1+/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant TransformationSemantic proximity Read ↗

Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-Associated Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms.Semantic proximity Read ↗

NeurofibromatosisSemantic proximity Read ↗

Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.Semantic proximity Read ↗

The NeurofibromatosesSemantic proximity Read ↗

Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1.Semantic proximity Read ↗

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromasSemantic proximity Read ↗

Insights into the Pathogenesis of NF1-Associated NeoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.