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Article

Update on pharmacogenetics in cancer chemotherapy.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2002

Innocenti F, Ratain M J

Abstract excerpt

This review describes how genetic differences among patients may change the therapeutic outcome in cancer chemotherapy. Severe toxicity in genetically predisposed patients is predominantly associated with mutations in drug metabolism enzyme genes, and an update on genetic intolerance to 6-mercaptopurine, 5-fluorouracil, and irinotecan is provided. Moreover, recent findings pointed out that the...

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PMID: 11916544
DOI: 10.1016/s0959-8049(01)00434-8

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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