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Article

Relationship between thymidylate synthase (TYMS) gene polymorphism and TYMS protein levels in patients with high-risk breast cancer.

Anticancer research - 1 Oct 2010

Fujishima Makoto, Inui Hiroki, Hashimoto Yukihiko, Azumi Tatsuya, Yamamoto Nao, Kato Hiroaki, Hojo Toshiya, Yamato Munehisa, Matsunami Nobuki, Shiozaki Hitoshi, Watatani Masahiro

Abstract excerpt

The thymidylate synthase gene (TYMS) has three functional polymorphisms which are associated with TYMS expression. To explore the predictability of TYMS polymorphisms for the sensitivity and toxicity of 5-fluorouracil (5-FU) in breast cancer patients, this study investigated the association between TYMS polymorphisms and TYMS protein expression in normal and tumour tissue specimens from 49 lymph node-positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21036767

Genes

TYMS

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Relationship between thymidylate synthase (TYMS) gene polymorphism and TYMS protein levels in patients with high-risk breast cancer.PMID 21036767Read ↗

Associations between polymorphisms at microRNA-binding sites in TYMS and breast cancer risk among Chinese womenSemantic proximity Read ↗

The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

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Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.Semantic proximity Read ↗

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Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer.Semantic proximity Read ↗

Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients.Semantic proximity Read ↗

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).Semantic proximity Read ↗

MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cellsSemantic proximity Read ↗

Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients.Semantic proximity Read ↗

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