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Article

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

Molecular and cellular biology - 15 May 2016

Frej Anna D, Clark Jonathan, Le Roy Caroline I, Lilla Sergio, Thomason Peter A, Otto Grant P, Churchill Grant, Insall Robert H, Claus Sandrine P, Hawkins Phillip, Stephens Len, Williams Robin S B

Abstract excerpt

Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer's disease. To date, most inositol studies have focused on the molecular and cellular effects of inositol depletion without considering Ino1 levels. Here we employ a simple eukaryote, Dictyostelium discoideum, to demonstrate distinct effects of...

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Identifiers

PMID: 26951199
DOI: 10.1128/MCB.00039-16
PMCID: PMC4859692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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