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Article

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate.

The EMBO journal - 17 May 1999

Williams R S, Eames M, Ryves W J, Viggars J, Harwood A J

Abstract excerpt

The therapeutic properties of lithium ions (Li+) are well known; however, the mechanism of their action remains unclear. To investigate this problem, we have isolated Li+-resistant mutants from Dictyostelium. Here, we describe the analysis of one of these mutants. This mutant lacks the Dictyostelium prolyl oligopeptidase gene (dpoA). We have examined the relationship between dpoA and the two major biological...

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Identifiers

PMID: 10329620
DOI: 10.1093/emboj/18.10.2734
PMCID: PMC1171355

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Source receipt: pubmed, retrieved 7 Sept 2026.

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