Article
Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol.
Molecular microbiology - 1 Feb 2007
Azab Abed N, He Quan, Ju Shulin, Li Guiling, Greenberg Miriam L
Abstract excerpt
Studies have shown that the inositol biosynthetic pathway and the enzyme glycogen synthase kinase-3 (GSK-3) are targets of the mood-stabilizing drugs lithium and valproate. However, a relationship between these targets has not been previously described. We hypothesized that GSK-3 may play a role...
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