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Article

Evidence for large diversity in the human transcriptome created by Alu RNA editing.

Nucleic acids research - 1 Nov 2009

Barak Michal, Levanon Erez Y, Eisenberg Eli, Paz Nurit, Rechavi Gideon, Church George M, Mehr Ramit

Abstract excerpt

Adenosine-to-inosine (A-to-I) RNA editing alters the original genomic content of the human transcriptome and is essential for maintenance of normal life in mammals. A-to-I editing in Alu repeats is abundant in the human genome, with many thousands of expressed Alu sequences undergoing editing. Little is known so far about the contribution of Alu editing to transcriptome complexity. Transcripts derived from a...

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PMID: 19740767
DOI: 10.1093/nar/gkp729
PMCID: PMC2777429

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