Article
Dynamic landscape and regulation of RNA editing in mammals.
Nature - 11 Oct 2017
Tan Meng How, Li Qin, Shanmugam Raghuvaran, Piskol Robert, Kohler Jennefer, Young Amy N, Liu Kaiwen Ivy, Zhang Rui, Ramaswami Gokul, Ariyoshi Kentaro, Gupte Ankita, Keegan Liam P, George Cyril X, Ramu Avinash, Huang Ni, Pollina Elizabeth A, Leeman Dena S, Rustighi Alessandra, Goh Y P Sharon, Chawla Ajay, Del Sal Giannino, Peltz Gary, Brunet Anne, Conrad Donald F, Samuel Charles E, O'Connell Mary A, Walkley Carl R, Nishikura Kazuko, Li Jin Billy
Abstract excerpt
Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules. Although many editing sites have recently been discovered, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood. Here we report dynamic...
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