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Article

The mechanism of acentrosomal spindle assembly in human oocytes

17 Nov 2022

Abstract excerpt

Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However, the mechanisms behind spindle assembly in human oocytes remain largely unknown. We used three-dimensional high-resolution imaging of more than 2000 human oocytes to identify a structure that we named the human oocyte microtubule organizing center (huoMTOC). The proteins TACC3, CCP110, CKAP5, and DISC1 were found to be essential...

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PMID: 36395215
DOI: 10.1126/science.abq7361

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