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Article

Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.

Autophagy - 1 Aug 2010

Zhou Xiang, Wang Fan

Abstract excerpt

PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal...

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Identifiers

PMID: 20562532
DOI: 10.4161/auto.6.6.12511
PMCID: PMC3321846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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