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Article

PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte.

Autophagy - 1 Jun 2013

Chen Jian-Kang

Abstract excerpt

The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 (pdKO) /mVps34 (pdKO) ) mice and demonstrated an...

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Identifiers

PMID: 23518611
DOI: 10.4161/auto.24230
PMCID: PMC3672302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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