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Article

Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.

The Journal of biological chemistry - 2 Nov 2012

Wang Ke, Yang Zhifen, Liu Xu, Mao Kai, Nair Usha, Klionsky Daniel J

Abstract excerpt

Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic cells from stress, starvation, and microbial infection. This process must be tightly controlled because too little or too much autophagy can be deleterious to cellular physiology. The phosphatidylinositol (PtdIns) 3-kinase Vps34 is a lipid kinase that regulates autophagy, but the role of other PtdIns kinases has not...

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Identifiers

PMID: 22977244
DOI: 10.1074/jbc.M112.371591
PMCID: PMC3488067

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