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Article

PIKE is essential for oligodendroglia development and CNS myelination.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2014

Chan Chi Bun, Liu Xia, Zhao Lixia, Liu Guanglu, Lee Chi Wai, Feng Yue, Ye Keiqang

Abstract excerpt

Oligodendrocyte (OL) differentiation and myelin development are complex events regulated by numerous signal transduction factors. Here, we report that phosphoinositide-3 kinase enhancer L (PIKE-L) is required for OL development and myelination. PIKE-L expression is up-regulated when oligodendrocyte progenitor cells commit to differentiation. Conversely, depleting phosphoinositide-3 kinase enhancer (PIKE)...

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Identifiers

PMID: 24449917
DOI: 10.1073/pnas.1318185111
PMCID: PMC3918755

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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