Article
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.
Genes & development - 15 Jun 2010
van Riggelen Jan, Müller Judith, Otto Tobias, Beuger Vincent, Yetil Alper, Choi Peter S, Kosan Christian, Möröy Tarik, Felsher Dean W, Eilers Martin
Abstract excerpt
The Myc protein suppresses the transcription of several cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is important for Myc's ability to induce or maintain tumorigenesis is not known. Here we show that the oncogenic potential of a point mutant of Myc (MycV394D) that is selectively deficient in binding to Miz1 is greatly attenuated. Binding of Myc to Miz1 is continuously...
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