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Article

Transforming Growth Factor β-Mediated Transcriptional Repression of c-<i>myc</i> Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

1 Mar 2004

Abstract excerpt

Smad proteins are the most well-characterized intracellular effectors of the transforming growth factor beta (TGF-beta) signal. The ability of the Smads to act as transcriptional activators via TGF-beta-induced recruitment to Smad binding elements (SBE) within the promoters of TGF-beta target genes has been firmly established. However, the elucidation of the molecular mechanisms involved in TGF-beta-mediated...

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PMID: 14993291
DOI: 10.1128/mcb.24.6.2546-2559.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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