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Article

Role of TGF-β and the Tumor Microenvironment During Mammary Tumorigenesis

1 Oct 2011

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that functions to inhibit mammary tumorigenesis by directly inducing mammary epithelial cells (MECs) to undergo cell cycle arrest or apoptosis, and to secrete a variety of cytokines, growth factors, and extracellular matrix proteins that maintain cell and tissue homeostasis. Genetic and epigenetic events that transpire during mammary...

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PMID: 22268294
DOI: 10.3727/105221611x13176664479322

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