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Article

New tricks for an old fox: Impact of TGFβ on the DNA damage response and genomic stability

2 Sept 2014

Abstract excerpt

Transforming growth factor-β (TGFβ) is a well-known master regulator of cellular proliferation and is a critical factor in the maintenance of tissue homeostasis. TGFβ is classically defined as a tumor suppressor that functions in the early stages of carcinogenesis, yet paradoxically it functions as a tumor promoter in established cancers. Less well studied is its role in maintaining genomic stability through its...

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PMID: 25185158
DOI: 10.1126/scisignal.2005474

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