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Article

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and Tumorigenesis

26 May 2022

Abstract excerpt

Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian development and disease, particularly cancer, has constantly been updated. Mounting evidence has confirmed that TGF-β is the principal regulator of the immune system, as deprivation of TGF-β signaling completely abrogates adaptive immunity....

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PMID: 35720407
DOI: 10.3389/fimmu.2022.891268

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