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Article

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

27 Jul 2018

Abstract excerpt

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this...

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PMID: 30060514
DOI: 10.3390/cancers10080247

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