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Article

Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.

Biophysical journal - 16 Jun 2010

Liang Ping, Chen Hao, Cui Yuanyuan, Lei Lei, Wang Kewei

Abstract excerpt

KChIP4a shows a high homology with other members of the family of Kv channel-interacting proteins (KChIPs) in the conserved C-terminal core region, but exhibits a unique modulation of Kv4 channel gating and surface expression. Unlike KChIP1, the KChIP4 splice variant KChIP4a has been shown to inhibit surface expression and function as a suppressor of channel inactivation of Kv4. In this study, we sought to...

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Identifiers

PMID: 20550899
DOI: 10.1016/j.bpj.2010.03.044
PMCID: PMC2884241

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Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.PMID 20550899Read ↗

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