Article
Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size.
Leukemia research - 1 Feb 2011
Nomdedeu J, Bussaglia E, Villamor N, Martinez C, Esteve J, Tormo M, Estivill C, Queipo M P, Guardia R, Carricondo M, Hoyos M, Llorente A, Juncà J, Gallart M, Domingo A, Bargay J, Mascaró M, Moraleda J M, Florensa L, Ribera J M, Gallardo D, Brunet S, Aventin A, Sierra J
Abstract excerpt
NPM mutations are the most common genetic abnormalities found in non-promyelocytic AML. NPM-positive patients usually show a normal karyotype, a peculiar morphologic appearance with frequent monocytic traits and good prognosis in the absence of an associated FLT3 mutation. This report describes the immunophenotypic and genetic characteristics of a consecutive series of NPM-mutated de novo AML patients enroled in...
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