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Article

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.

Gastroenterology - 1 Sept 2010

Kosinski Cynthia, Stange Daniel E, Xu Chuanrui, Chan Annie Sy, Ho Coral, Yuen Siu Tsan, Mifflin Randy C, Powell Don W, Clevers Hans, Leung Suet Yi, Chen Xin

Abstract excerpt

BACKGROUND & AIMS: Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and the mechanisms by which perturbations in epithelial-mesenchymal interactions affect ISC fate. METHODS: We generated mice with intestinal epithelial-specific disruption of Ihh. Gross and...

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Identifiers

PMID: 20542037
DOI: 10.1053/j.gastro.2010.06.014
PMCID: PMC2930094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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