Article
Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.
Gastroenterology - 1 Jan 2015
Büller Nikè V J A, Rosekrans Sanne L, Metcalfe Ciara, Heijmans Jarom, van Dop Willemijn A, Fessler Evelyn, Jansen Marnix, Ahn Christina, Vermeulen Jacqueline L M, Westendorp B Florien, Robanus-Maandag Els C, Offerhaus G Johan, Medema Jan Paul, D'Haens Geert R A M, Wildenberg Manon E, de Sauvage Frederic J, Muncan Vanesa, van den Brink Gijs R
Abstract excerpt
BACKGROUND & AIMS: Indian hedgehog (IHH) is an epithelial-derived signal in the intestinal stroma, inducing factors that restrict epithelial proliferation and suppress activation of the immune system. In addition to these rapid effects of IHH signaling, IHH is required to maintain a stromal phenotype in which myofibroblasts and smooth muscle cells predominate. We investigated the role of IHH signaling during...
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