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Article

ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis

2 Jan 2017

Abstract excerpt

Abstract The intestinal epithelium continually self‐renews and can rapidly regenerate after damage. Dysregulation of intestinal epithelial homeostasis leads to severe inflammatory bowel disease. Additionally, aberrant signaling by the secreted protein angiopoietin‐like protein 2 (ANGPTL2) causes chronic inflammation in a variety of diseases. However, little is known about the physiologic role of ANGPTL2 in normal...

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PMID: 28043948
DOI: 10.15252/embj.201695690

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