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Article

Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut.

eLife - 11 Mar 2014

Tian Aiguo, Jiang Jin

Abstract excerpt

Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP signaling is asymmetric between ISC and its differentiated daughter cell. Two BMP ligands, Dpp...

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Identifiers

PMID: 24618900
DOI: 10.7554/eLife.01857
PMCID: PMC3948108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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