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Article

CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization?

Pediatrics - 1 Oct 2010

Vicencio Alfin G, Chupp Geoffrey L, Tsirilakis Kalliope, He Xiaoxuan, Kessel Aaron, Nandalike Kiran, Veler Haviva, Kipperman Stacy, Young Michael C, Goldman David L

Abstract excerpt

Fungi can exacerbate symptoms in patients with asthma. To our knowledge, genetic risk factors for fungal-associated asthma have not been described. We present here the cases of 6 children who carried the diagnosis of severe asthma with fungal sensitization, 3 of whom were treated with and responded clinically to itraconazole therapy. All 6 patients were heterozygous for a 24-base pair duplication in the CHIT1...

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Source

Identifiers

PMID: 20819891
DOI: 10.1542/peds.2010-0321

Genes

CHIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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