Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.

BMC medical genetics - 10 Jun 2010

Hradsky Ondrej, Dusatkova Petra, Lenicek Martin, Bronsky Jiri, Nevoral Jiri, Vitek Libor, Lukas Milan, Zeniskova Ivana, Cinek Ondrej

Abstract excerpt

BACKGROUND: The CTLA4 (cytotoxic T-lymphocyte antigen 4) gene is associated with several immunopathologic diseases and because of its important immuno-regulatory role it may be considered also a plausible candidate for a genetic association with inflammatory bowel diseases. Previously published studies found no association of CTLA4 with Crohn's disease itself, but some indicated an association with its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Haplotypes

Share to Inflammatory Bowel Diseases

Share to Risk Factors

Share to T-Lymphocytes, Cytotoxic

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20537165
DOI: 10.1186/1471-2350-11-91
PMCID: PMC2894789

Genes

CTLA4
NOD2

Variants

rs11209026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.PMID 20537165Read ↗

Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish population.Semantic proximity Read ↗

Association of IL23R p.381Gln and ATG16L1 p.197Ala with Crohn disease in the Czech population.Semantic proximity Read ↗

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.Semantic proximity Read ↗

The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease.Semantic proximity Read ↗

Epistatic interaction between TLR4 and NOD2 in patients with Crohn's Disease: relation with risk and phenotype in a Spanish cohort.Semantic proximity Read ↗

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.Semantic proximity Read ↗

CTLA4 CT60 single-nucleotide polymorphism is associated with Slovenian inflammatory bowel disease patients and regulates expression of CTLA4 isoforms.Semantic proximity Read ↗

Association of CTLA-4 variants with susceptibility to inflammatory bowel disease: a meta-analysis.Semantic proximity Read ↗

Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis.Semantic proximity Read ↗

Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn's disease patients.Semantic proximity Read ↗

Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn's Disease: On the Way to Personalized Medicine?Semantic proximity Read ↗

Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.