OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.

Abstract excerpt

CONTEXT: Several single-nucleotide polymorphisms (SNPs) have been reliably associated with areal bone mineral density (aBMD) in genome-wide association studies of mostly older subjects. OBJECTIVE: We aimed to test those SNPs for an association with peripheral quantitative computed tomography (pQCT) bone measures in two young cohorts. DESIGN AND STUDY PARTICIPANTS: We genotyped nine SNPs from the most promising...

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• Bone Density
• Genetic Association Studies
• Longitudinal Studies
• Obesity
• Osteoporosis