Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.

doi:10.1002/jbmr.78

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2010

Roshandel Delnaz, Holliday Kate L, Pye Stephen R, Boonen Steven, Borghs Herman, Vanderschueren Dirk, Huhtaniemi Ilpo T, Adams Judith E, Ward Kate A, Bartfai Gyorgy, Casanueva Felipe, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Han Thang S, Kula Krzysztof, Lean Michael E, Pendleton Neil, Punab Margus, Silman Alan J, Wu Frederick C, Thomson Wendy, O'Neill Terence W

Abstract excerpt

The aim of this study was to determine if single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (r(2) > or = 0.8) were selected for RANKL, RANK, and OPG and their 10-kb flanking regions. Selected tag SNPs plus five SNPs near RANKL and OPG, associated with BMD in published genome-wide association studies (GWAS), were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Absorptiometry, Photon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Bone Density

Share to Bone Remodeling

Share to Osteoprotegerin

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Ultrasonography

Source

Open in PubMed

Identifiers

PMID: 20205168
DOI: 10.1002/jbmr.78

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.PMID 20205168Read ↗

Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.Semantic proximity Read ↗

Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men.Semantic proximity Read ↗

Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.Semantic proximity Read ↗

OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.Semantic proximity Read ↗

Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis.Semantic proximity Read ↗

Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women.Semantic proximity Read ↗

Allelic variations of RANKL/OPG signaling system are related to bone mineral density and in vivo gene expression.Semantic proximity Read ↗

VDR, RANKL and OPG polymorphisms as possible predisposing cofactors of postmenopausal osteoporosis: explorative study in Italian population.Semantic proximity Read ↗

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.Semantic proximity Read ↗

Genetic predictors of skeletal outcomes in healthy fertile women: the Bonturno study.Semantic proximity Read ↗

Common Variants of the OPG gene Are Associated with Osteoporosis Risk: A Meta-Analysis.Semantic proximity Read ↗

RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.