Article
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
Human molecular genetics - 15 Apr 2009
Timpson Nicholas J, Tobias Jon H, Richards J Brent, Soranzo Nicole, Duncan Emma L, Sims Anne-Marie, Whittaker Pamela, Kumanduri Vasudev, Zhai Guangju, Glaser Beate, Eisman John, Jones Graeme, Nicholson Geoff, Prince Richard, Seeman Ego, Spector Tim D, Brown Matthew A, Peltonen Leena, Smith George Davey, Deloukas Panos, Evans David M
Abstract excerpt
Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related traits in 1518 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). We compared results with a scan of 134 adults with high or low hip BMD. We identified associations...
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