Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.

doi:10.1371/journal.pgen.1001217

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Article

Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.

PLoS genetics - 18 Nov 2010

Paternoster Lavinia, Lorentzon Mattias, Vandenput Liesbeth, Karlsson Magnus K, Ljunggren Osten, Kindmark Andreas, Mellstrom Dan, Kemp John P, Jarett Caroline E, Holly Jeff M P, Sayers Adrian, St Pourcain Beate, Timpson Nicholas J, Deloukas Panos, Davey Smith George, Ring Susan M, Evans David M, Tobias Jon H, Ohlsson Claes

Abstract excerpt

Previous genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal expansion, cortical bone mineral density (BMD(C)) cortical thickness, trabecular number, and trabecular thickness, which may be under distinct biological and genetic control. We have carried out a GWA...

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PMID: 21124946
DOI: 10.1371/journal.pgen.1001217
PMCID: PMC2987837

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