Article

Endocrine islet β-cell subtypes with differential function are derived from biochemically distinct embryonic endocrine islet progenitors that are regulated by maternal nutrients

2024-03-07

Abstract excerpt

<title>Abstract</title> <p>Endocrine islet b cells comprise heterogenous cell subsets. Yet when/how these subsets are produced and how stable they are remain unknown. Addressing these questions is important for preventing/curing diabetes, because lower numbers of b cells with better secretory function is a high risk of this disease. Using combinatorial cell lineage tracing, scRNA-seq, and DNA methylation analysis...

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Literature Corpus work: 9558ac35-935e-5566-ad30-ac33f38ae2cb
DOI: 10.21203/rs.3.rs-3946483/v1

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