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Article

Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol

2 Feb 2015

Abstract excerpt

Alcohol is the most commonly abused drug worldwide, and chronic alcohol consumption is a major etiological factor in the development of multiple pathological sequelae, including alcoholic cardiomyopathy and hepatic cirrhosis. Here, we identify regulator of G protein signaling 6 (RGS6) as a critical regulator of both alcohol-seeking behaviors and the associated cardiac and hepatic morbidities through two...

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PMID: 25646431
DOI: 10.1073/pnas.1418795112

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