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Article

Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2010

York Brian, Yu Chundong, Sagen Jørn V, Liu Zhaoliang, Nikolai Bryan C, Wu Ray-Chang, Finegold Milton, Xu Jianming, O'Malley Bert W

Abstract excerpt

Here we demonstrate that reprogramming steroid receptor coactivator-3 (SRC-3) function by changing its posttranslational modification (PTM) code drastically influences systems biology. These findings support the physiological importance of PTMs in directing in vivo functions of a master coregulator. We previously reported that the transactivation potential of SRC-3 is controlled in part by PTMs, although this...

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Identifiers

PMID: 20534466
DOI: 10.1073/pnas.1005262107
PMCID: PMC2890746

Genes

SRC
IGF1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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