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Article

Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout.

International journal of biological sciences - 23 Jul 2008

Liu Zhaoliang, Liao Lan, Zhou Suoling, Xu Jianming

Abstract excerpt

The steroid receptor coactivator-3 (SRC-3), also known as AIB1, ACTR, p/CIP and NCOA3, is a transcriptional coactivator for nuclear receptors and certain other transcription factors. SRC-3 is widely expressed and plays important physiological functions and pathogenic roles in breast and prostate cancers. SRC-3 knockout (SRC-3(-/-)) mice display genetic background-dependent embryonic lethality and multiple local...

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Source

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Identifiers

PMID: 18690289
DOI: 10.7150/ijbs.4.202
PMCID: PMC2491728

Genes

SRC
NCOA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout.PMID 18690289Read ↗

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